Target：CBP20

Fields：Nucleocytoplasmic transport;mRNA surveillance pathway;Spliceosome

Gene Name：NCBP2

Protein Name：Nuclear cap-binding protein subunit 2

Human Gene Id：22916

Human Swiss Prot No：P52298

Mouse Gene Id：68092

Mouse Swiss Prot No：Q9CQ49

Immunogen：The antiserum was produced against synthesized peptide derived from human NCBP2. AA range:10-59

Specificity：CBP20 Polyclonal Antibody detects endogenous levels of CBP20 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NCBP2;CBP20;PIG55;Nuclear cap-binding protein subunit 2;20 kDa nuclear cap-binding protein;Cell proliferation-inducing gene 55 protein;NCBP 20 kDa subunit;CBP20;NCBP-interacting protein 1;NIP1

Observed Band(KD)：18kD

Background： The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:Involved in mediating U snRNA export from the nucleus. Binds to 5' capped mRNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RRM NCBP2 family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity). Heterodimer with NCBP1. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.,

Subcellular Location：Nucleus . Cytoplasm .

Expression： Cervix,Cervix carcinoma,Human small intestine,