Target：MARCH3

Gene Name：MARCH3

Protein Name：E3 ubiquitin-protein ligase MARCH3

Human Gene Id：115123

Human Swiss Prot No：Q86UD3

Mouse Gene Id：320253

Mouse Swiss Prot No：Q8BRX9

Rat Gene Id：364878

Rat Swiss Prot No：Q5XIE5

Immunogen：The antiserum was produced against synthesized peptide derived from human MARCH3. AA range:111-160

Specificity：MARCH3 Polyclonal Antibody detects endogenous levels of 40605 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MARCH3;RNF173;E3 ubiquitin-protein ligase MARCH3;Membrane-associated RING finger protein 3;Membrane-associated RING-CH protein III;MARCH-III;RING finger protein 173

Observed Band(KD)：29kD

Background： This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013],

Function：domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with MARCH2 and STX6.,

Subcellular Location：Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .

Expression： Brain,Thalamus,