Target：THC2

Gene Name：MASTL

Protein Name：Serine/threonine-protein kinase greatwall

Human Gene Id：84930

Human Swiss Prot No：Q96GX5

Mouse Swiss Prot No：Q8C0P0

Immunogen：Synthesized peptide derived from the C-terminal region of human MASTL.

Specificity：MASTL Polyclonal Antibody detects endogenous levels of MASTL protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MASTL;GW;GWL;THC2;Serine/threonine-protein kinase greatwall;GW;GWL;hGWL;Microtubule-associated serine/threonine-protein kinase-like;MAST-L

Observed Band(KD)：100kD

Background： This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MASTL are the cause of thrombocytopenia type 2 (THC2) [MIM:188000]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.,function:Putative serine/threonine kinase which may be involved in megakaryocyte differentiation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cleavage furrow . During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. .

Expression： Epithelium,Placenta,