Target：Cathepsin H

Fields：Lysosome;Apoptosis

Gene Name：CTSH

Protein Name：Pro-cathepsin H

Human Gene Id：1512

Human Swiss Prot No：P09668

Mouse Swiss Prot No：P49935

Immunogen：Synthesized peptide derived from Cathepsin H . at AA range: 220-300

Specificity：Cathepsin H Polyclonal Antibody detects endogenous levels of Cathepsin H protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CTSH;CPSB;Pro-cathepsin H

Observed Band(KD)：40kD

Background： The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],

Function：catalytic activity:Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.,

Subcellular Location：Lysosome.

Expression： Cartilage,Eye,Kidney,Liver,Lung,Salivary gland,