Target：CARKL
Fields：Metabolic pathways
Gene Name：SHPK
Protein Name：Sedoheptulokinase
Human Gene Id：23729
Human Swiss Prot No：Q9UHJ6
Mouse Gene Id：74637
Mouse Swiss Prot No：Q9D5J6
Immunogen：The antiserum was produced against synthesized peptide derived from human CARKL. AA range:31-80
Specificity：CARKL Polyclonal Antibody detects endogenous levels of CARKL protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：SHPK;CARKL;Sedoheptulokinase;SHK;Carbohydrate kinase-like protein
Observed Band(KD)：55kD
Background：sedoheptulokinase(SHPK) Homo sapiens The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008],
Function：catalytic activity:ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate.,disease:Deficiency of the SHPK gene in cystinosis patients with a common 57-Kb deletion causes urinary accumulation of sedoheptulose and erythritol.,similarity:Belongs to the FGGY kinase family.,tissue specificity:Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.,
Subcellular Location：Cytoplasm .
Expression：Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.
