Target：CARD 10

Fields：NF-kappa B signaling pathway

Gene Name：CARD10

Protein Name：Caspase recruitment domain-containing protein 10

Human Gene Id：29775

Human Swiss Prot No：Q9BWT7

Mouse Gene Id：105844

Mouse Swiss Prot No：P58660

Immunogen：The antiserum was produced against synthesized peptide derived from human CARD10. AA range:481-530

Specificity：CARD 10 Polyclonal Antibody detects endogenous levels of CARD 10 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CARD10;CARMA3;Caspase recruitment domain-containing protein 10;CARD-containing MAGUK protein 3;Carma 3

Observed Band(KD)：120kD

Background： The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008],

Function：caution:Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.,function:Activates NF-kappa-B via BCL10 and IKK.,similarity:Contains 1 CARD domain.,subunit:CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10.,tissue specificity:Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.,

Subcellular Location：Cytoplasm .

Expression：Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.