Target：Carbonyl Reductase 3

Fields：Arachidonic acid metabolism;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways

Gene Name：CBR3

Protein Name：Carbonyl reductase [NADPH] 3

Human Gene Id：874

Human Swiss Prot No：O75828

Mouse Gene Id：109857

Mouse Swiss Prot No：Q8K354

Immunogen：The antiserum was produced against synthesized peptide derived from human CBR3. AA range:151-200

Specificity：Carbonyl Reductase 3 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CBR3;Carbonyl reductase [NADPH] 3;NADPH-dependent carbonyl reductase 3

Observed Band(KD)：31kD

Background： Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008],

Function：catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,

Subcellular Location：Cytoplasm .

Expression：Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.