Target：Carbonyl Reductase 1

Fields：Arachidonic acid metabolism;Folate biosynthesis;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Chemical carcinogenesis - DNA adducts;Chemical carcinogenesis - reactive oxygen species

Gene Name：CBR1

Protein Name：Carbonyl reductase [NADPH] 1

Human Gene Id：873

Human Swiss Prot No：P16152

Mouse Swiss Prot No：P48758

Immunogen：The antiserum was produced against synthesized peptide derived from human CBR1. AA range:181-230

Specificity：Carbonyl Reductase 1 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CBR1;CBR;CRN;Carbonyl reductase [NADPH] 1;15-hydroxyprostaglandin dehydrogenase [NADP(+)];NADPH-dependent carbonyl reductase 1;Prostaglandin 9-ketoreductase;Prostaglandin-E(2) 9-reductase

Observed Band(KD)：32kD

Background： The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013],

Function：catalytic activity:(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.,catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.,catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,function:Catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. Can convert prostaglandin E2 to prostaglandin F2-alpha.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Monomer.,

Subcellular Location：Cytoplasm .

Expression：Expressed in kidney (at protein level).