Target：CaMKIIδ

Fields：ErbB signaling pathway;Calcium signaling pathway;cAMP signaling pathway;HIF-1 signaling pathway;Oocyte meiosis;Necroptosis;Adrenergic signaling in cardiomyocytes;Wnt signaling pathway;Axon guidance;Circadian entrainment;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Melanogenesis;Oxytocin signaling pathway;Glucagon signaling pathway;Aldosterone synthesis and secretion;Cushing syndrome;Gastric acid secretion;Parkinson disease;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Tuberculosis;Pathways in cancer;Proteoglycans in cancer;Glioma;Diabetic cardiomyopathy;Lipid and atherosclerosis

Gene Name：CAMK2D

Protein Name：Calcium/calmodulin-dependent protein kinase type II subunit delta

Human Gene Id：817

Human Swiss Prot No：Q13557

Mouse Gene Id：108058

Mouse Swiss Prot No：Q6PHZ2

Rat Gene Id：24246

Rat Swiss Prot No：P15791

Immunogen：Synthesized peptide derived from the Internal region of human CaMKIIδ.

Specificity：CaMKIIδ Polyclonal Antibody detects endogenous levels of CaMKIIδ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CAMK2D;CAMKD;Calcium/calmodulin-dependent protein kinase type II subunit delta;CaM kinase II subunit delta;CaMK-II subunit delta

Observed Band(KD)：56kD

Background： The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,miscellaneous:Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,tissue specificity:Expressed in cardiac muscle and skeletal mus

Subcellular Location：Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .

Expression：Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.