Target：CaMKIIβ/γ

Fields：ErbB signaling pathway;Calcium signaling pathway;cAMP signaling pathway;HIF-1 signaling pathway;Oocyte meiosis;Necroptosis;Adrenergic signaling in cardiomyocytes;Wnt signaling pathway;Axon guidance;Circadian entrainment;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Melanogenesis;Oxytocin signaling pathway;Glucagon signaling pathway;Aldosterone synthesis and secretion;Cushing syndrome;Gastric acid secretion;Parkinson disease;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Tuberculosis;Pathways in cancer;Proteoglycans in cancer;Glioma;Diabetic cardiomyopathy;Lipid and atherosclerosis

Gene Name：CAMK2B/CAMK2G

Protein Name：Calcium/calmodulin-dependent protein kinase type II subunit beta/gamma

Human Gene Id：818/816

Human Swiss Prot No：Q13555/Q13554

Mouse Gene Id：12325/12323

Rat Gene Id：171140/24245

Rat Swiss Prot No：P11730/P08413

Immunogen：The antiserum was produced against synthesized peptide derived from human CaMK2 beta/gamma. AA range:509-558

Specificity：CaMKIIβ/γ Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CAMK2G;CAMK;CAMK-II;CAMKG;Calcium/calmodulin-dependent protein kinase type II subunit gamma;CaM kinase II subunit gamma;CaMK-II subunit gamma;CAMK2B;CAM2;CAMK2;CAMKB;Calcium/calmodulin-dependent protein kinase type II subunit bet

Observed Band(KD)：62kD

Background： The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,

Subcellular Location：Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .

Expression：Expressed in skeletal muscle.