Target：CALY

Fields：Dopaminergic synapse

Gene Name：CALY DRD1IP

Protein Name：Neuron-specific vesicular protein calcyon

Human Gene Id：50632

Human Swiss Prot No：Q9NYX4

Mouse Swiss Prot No：Q9DCA7

Rat Swiss Prot No：P58821

Immunogen：Synthesized peptide derived from human protein . at AA range: 1-80

Specificity：CALY Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：23kD

Background：calcyon neuron specific vesicular protein(CALY) Homo sapiens The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008],

Function：caution:Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.,function:Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.,PTM:Glycosylated.,similarity:Belongs to the NSG family.,subunit:Interacts with CLTA.,tissue specificity:Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.,

Subcellular Location：Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.

Expression：Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.