Target：RNase Z2

Gene Name：ELAC2

Protein Name：Zinc phosphodiesterase ELAC protein 2

Human Gene Id：60528

Human Swiss Prot No：Q9BQ52

Mouse Swiss Prot No：Q80Y81

Immunogen：The antiserum was produced against synthesized peptide derived from human ELAC2. AA range:161-210

Specificity：RNase Z2 Polyclonal Antibody detects endogenous levels of RNase Z2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ELAC2;HPC2;Zinc phosphodiesterase ELAC protein 2;ElaC homolog protein 2;Heredity prostate cancer protein 2;Ribonuclease Z 2;RNase Z 2;tRNA 3 endonuclease 2;tRNase Z 2

Molecular Weight(Da)：92kD

Background： The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],

Function：catalytic activity:Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.,cofactor:Zinc.,disease:Defects in ELAC2 are involved in prostate cancer (CaP) [MIM:176807].,function:Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.,similarity:Belongs to the RNase Z family.,subunit:Homodimer.,tissue specificity:Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.,

Subcellular Location：Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid . Nucleus . Mainly mitochondrial.

Expression：Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.