Target：BRMS-1

Gene Name：BRMS1

Protein Name：Breast cancer metastasis-suppressor 1

Human Gene Id：25855

Human Swiss Prot No：Q9HCU9

Mouse Gene Id：107392

Mouse Swiss Prot No：Q99N20

Rat Gene Id：1.00912e+008

Rat Swiss Prot No：Q5M7T3

Immunogen：The antiserum was produced against synthesized peptide derived from human BRMS1. AA range:21-70

Specificity：BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BRMS1;Breast cancer metastasis-suppressor 1

Observed Band(KD)：28kD

Background： This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Function：function:May be a mediator of metastasis suppression in breast carcinoma.,similarity:Belongs to the BRMS1 family.,tissue specificity:Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,

Subcellular Location：Nucleus. Cytoplasm. Predominantly nuclear.

Expression：Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.