Target：BOREA

Gene Name：CDCA8 PESCRG3

Protein Name：Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)

Human Gene Id：55143

Human Swiss Prot No：Q53HL2

Mouse Swiss Prot No：Q8BHX3

Rat Swiss Prot No：Q6AXW0

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：BOREA Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：30kD

Background：cell division cycle associated 8(CDCA8) Homo sapiens This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013],

Function：developmental stage:Cell-cycle regulated. Increases during G2/M phase and then reduces after exit from M phase.,function:Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA.,miscellaneous:Cells lacking CDCA8 display a slight decrease in histone H3 'Ser-10' phosphorylation, suggesting that the CPC complex mediates phosphorylation of 'Ser-10' of histone H3.,similarity:Belongs to the borealin family.,subcellular location:Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphas

Subcellular Location：Nucleus, nucleolus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. .

Expression： Colon,Coronary arterial endothelium,Embryo,Epithelium,Kidney,Lung,