Target：BOC

Fields：Hedgehog signaling pathway;Axon guidance

Gene Name：BOC UNQ604/PRO1190

Protein Name：Brother of CDO (Protein BOC)

Human Gene Id：91653

Human Swiss Prot No：Q9BWV1

Mouse Swiss Prot No：Q6AZB0

Immunogen：Synthesized peptide derived from human protein . at AA range: 630-710

Specificity：BOC Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：122kD

Background： The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014],

Function：function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.,miscellaneous:The C-terminal cytoplasmic domain is not required for the stimuation of myogenesis.,PTM:N-glycosylated.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Enriched at sites of cell-cell contact.,subunit:Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.,tissue specificity:Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Enriched at sites of cell-cell contact.

Expression：Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.