Target：BMP-8B
Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Hippo signaling pathway;Thermogenesis
Gene Name：BMP8B
Protein Name：Bone morphogenetic protein 8B
Human Gene Id：656
Human Swiss Prot No：P34820
Mouse Swiss Prot No：P55105
Immunogen：The antiserum was produced against synthesized peptide derived from human BMP8B. AA range:261-310
Specificity：BMP-8B Polyclonal Antibody detects endogenous levels of BMP-8B protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：BMP8B;BMP8;Bone morphogenetic protein 8B;BMP-8;BMP-8B;Osteogenic protein 2;OP-2
Observed Band(KD)：45kD
Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],
Function：function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8b entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Subcellular Location：Secreted .
Expression： Hippocampus,Testis,
