Target：BMP-8A

Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Hippo signaling pathway;Thermogenesis

Gene Name：BMP8A

Protein Name：Bone morphogenetic protein 8A

Human Gene Id：353500

Human Swiss Prot No：Q7Z5Y6

Mouse Swiss Prot No：P34821

Immunogen：The antiserum was produced against synthesized peptide derived from human BMP8A. AA range:253-302

Specificity：BMP-8A Polyclonal Antibody detects endogenous levels of BMP-8A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BMP8A;Bone morphogenetic protein 8A;BMP-8A

Observed Band(KD)：45-55kD

Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],

Function：function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8A entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：Secreted .

Expression： Brain,Hippocampus,Thyroid gland,