Target：BMP-8
Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Hippo signaling pathway;Thermogenesis
Gene Name：BMP8A/BMP8B
Protein Name：Bone morphogenetic protein 8A/B
Human Gene Id：656
Human Swiss Prot No：P34820/Q7Z5Y6
Immunogen：The antiserum was produced against synthesized peptide derived from human BMP-8. AA range:41-90
Specificity：BMP-8 Polyclonal Antibody detects endogenous levels of BMP-8 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：BMP8B;BMP8;Bone morphogenetic protein 8B;BMP-8;BMP-8B;Osteogenic protein 2;OP-2;BMP8A;Bone morphogenetic protein 8A;BMP-8A
Molecular Weight(Da)：45kD
Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],
Function：function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8b entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Subcellular Location：Secreted .
Expression： Hippocampus,Testis,
