Target：BMP-6

Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Hippo signaling pathway;Ovarian steroidogenesis

Gene Name：BMP6

Protein Name：Bone morphogenetic protein 6

Human Gene Id：654

Human Swiss Prot No：P22004

Mouse Gene Id：12161

Mouse Swiss Prot No：P20722

Rat Gene Id：25644

Rat Swiss Prot No：Q04906

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human BMP6. AA range:341-390

Specificity：BMP-6 Polyclonal Antibody detects endogenous levels of BMP-6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BMP6;VGR;Bone morphogenetic protein 6;BMP-6;VG-1-related protein;VG-1-R;VGR-1

Observed Band(KD)：60kD

Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016],

Function：function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 6 entry,similarity:Belongs to the TGF-beta family.,subunit:Interacts with SOSTDC1.,

Subcellular Location：Secreted .

Expression： Bone,PCR rescued clones,