Target：BMP-5

Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Hippo signaling pathway

Gene Name：BMP5

Protein Name：Bone morphogenetic protein 5

Human Gene Id：653

Human Swiss Prot No：P22003

Mouse Gene Id：12160

Mouse Swiss Prot No：P49003

Immunogen：The antiserum was produced against synthesized peptide derived from human BMP-5. AA range:114-163

Specificity：BMP-5 Polyclonal Antibody detects endogenous levels of BMP-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BMP5;Bone morphogenetic protein 5;BMP-5

Observed Band(KD)：52kD

Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016],

Function：function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 5 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in the lung and liver.,

Subcellular Location：Secreted.

Expression：Expressed in the lung and liver.