Target：BAG2

Fields：Protein processing in endoplasmic reticulum

Gene Name：BAG2

Protein Name：BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)

Human Gene Id：9532

Human Swiss Prot No：O95816

Mouse Swiss Prot No：Q91YN9

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：BAG2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：23kD

Background： BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],

Function：function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.,similarity:Contains 1 BAG domain.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones.,

Subcellular Location：cytosol,

Expression： Uterus,