Target：MEK Kinase-6

Fields：MAPK signaling pathway

Gene Name：MAP3K6

Protein Name：Mitogen-activated protein kinase kinase kinase 6

Human Gene Id：9064

Human Swiss Prot No：O95382

Mouse Gene Id：53608

Mouse Swiss Prot No：Q9WTR2

Immunogen：The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330

Specificity：MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MAP3K6;ASK2;MAPKKK6;MEKK6;Mitogen-activated protein kinase kinase kinase 6;Apoptosis signal-regulating kinase 2

Molecular Weight(Da)：143kD

Background： This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,

Subcellular Location：intracellular,

Expression： Brain,PCR rescued clones,Skin,