Target：Glucagon Receptor

Fields：Neuroactive ligand-receptor interaction;Glucagon signaling pathway

Gene Name：GCGR

Protein Name：Glucagon receptor

Human Gene Id：2642

Human Swiss Prot No：P47871

Mouse Gene Id：14527

Mouse Swiss Prot No：Q61606

Rat Gene Id：24953

Rat Swiss Prot No：P30082

Immunogen：The antiserum was produced against synthesized peptide derived from human GLR. AA range:95-144

Specificity：Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GCGR;Glucagon receptor;GL-R

Observed Band(KD)：54kD

Background：glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010],

Function：disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. .

Expression： Liver,Placenta,