Target：GLRX1

Gene Name：GLRX GRX

Protein Name：Glutaredoxin-1 (Thioltransferase-1) (TTase-1)

Human Gene Id：2745

Human Swiss Prot No：P35754

Mouse Swiss Prot No：Q9QUH0

Rat Swiss Prot No：Q9ESH6

Immunogen：Synthesized peptide derived from human protein . at AA range: 40-120

Specificity：GLRX1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：11kD

Background： This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011],

Function：function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.,similarity:Belongs to the glutaredoxin family.,similarity:Contains 1 glutaredoxin domain.,

Subcellular Location：Cytoplasm.

Expression： Blood,Brain,Lens,Liver,Skin,Spleen,Urinary bladder,