Target：Meis1

Fields：Signaling pathways regulating pluripotency of stem cells;Transcriptional misregulation in cancer

Gene Name：MEIS1

Protein Name：Homeobox protein Meis1

Human Gene Id：4211

Human Swiss Prot No：O00470

Mouse Gene Id：17268

Mouse Swiss Prot No：Q60954

Immunogen：The antiserum was produced against synthesized peptide derived from human Meis1. AA range:229-278

Specificity：Meis1 Polyclonal Antibody detects endogenous levels of Meis1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MEIS1;Homeobox protein Meis1

Observed Band(KD)：37kD

Background： Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008],

Function：function:Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.,similarity:Belongs to the TALE/MEIS homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.,tissue specificity:Expressed at low level in normal immun

Subcellular Location：Nucleus .

Expression：Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.