Target：ME3

Fields：Pyruvate metabolism;Metabolic pathways;Carbon metabolism;PPAR signaling pathway

Gene Name：ME3

Protein Name：NADP-dependent malic enzyme mitochondrial

Human Gene Id：10873

Human Swiss Prot No：Q16798

Mouse Gene Id：109264

Mouse Swiss Prot No：Q8BMF3

Immunogen：The antiserum was produced against synthesized peptide derived from human ME3. AA range:545-594

Specificity：ME3 Polyclonal Antibody detects endogenous levels of ME3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ME3;NADP-dependent malic enzyme; mitochondrial;NADP-ME;Malic enzyme 3

Observed Band(KD)：67kD

Background： Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],

Function：catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,similarity:Belongs to the malic enzymes family.,tissue specificity:Expressed predominantly in organs with a low-division rate.,

Subcellular Location：Mitochondrion matrix.

Expression：Expressed predominantly in organs with a low-division rate.