Target：ARHGF

Gene Name：ARHGEF15 KIAA0915

Protein Name：Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)

Human Gene Id：22899

Human Swiss Prot No：O94989

Mouse Swiss Prot No：Q5FWH6

Immunogen：Synthesized peptide derived from human protein . at AA range: 560-640

Specificity：ARHGF Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：92kD

Background： Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010],

Function：function:Specific GEF for RhoA activation and the regulation of vascular smooth muscle contractility.,PTM:Phosphorylated on tyrosine residues upon EFNA1 stimulation.,similarity:Contains 1 DH (DBL-homology) domain.,subunit:Interacts with EPHA4.,tissue specificity:Expressed in the vascular smooth muscle of coronary artery.,

Subcellular Location：Cell projection, dendrite . Expressed exclusively in dendrites of the developing hippocampus. .

Expression：Expressed in the vascular smooth muscle of coronary artery.