Target：ATS10

Gene Name：ADAMTS10

Protein Name：A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-)

Human Gene Id：81794

Human Swiss Prot No：Q9H324

Mouse Swiss Prot No：P58459

Immunogen：Synthesized peptide derived from human protein . at AA range: 140-220

Specificity：ATS10 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：121kD

Background： This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008],

Function：cofactor:Binds 1 zinc ion per subunit.,disease:Defects in ADAMTS10 are a cause of the autosomal recessive form of Weill-Marchesani syndrome (WMS) [MIM:277600]. WMS is characterized by the association of short stature, brachydactyly, joint stiffness, eye anomalies, including microspherophakia, ectopia of the lenses, severe myopia, and glaucoma; and, occasionally, heart defects.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Widely expressed in adult tissues.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Widely expressed in adult tissues.