Target：ANPRA

Fields：Purine metabolism;Metabolic pathways;cGMP-PKG signaling pathway;cAMP signaling pathway;Vascular smooth muscle contraction;Thermogenesis;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Renin secretion;Aldosterone synthesis and secretion

Gene Name：NPR1 ANPRA

Protein Name：Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)

Human Gene Id：4881

Human Swiss Prot No：P16066

Mouse Swiss Prot No：P18293

Rat Swiss Prot No：P18910

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：ANPRA Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：116kD

Background： Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (A

Function：catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,function:Receptor for atrial natriuretic peptide. Has guanylate cyclase activity on binding of ANF.,miscellaneous:There seem to be at least three natriuretic peptide hormone receptors: two with guanylate cyclase activity (NPR1/ANP-A and NPR2/ANP-B) and one (NPR3/ANP-C) which is probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction.,PTM:Phosphorylation of the protein kinase-like domain is required for full activation by ANP.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression： Blood,Kidney,Placenta,Retina,