Target：ANO10

Gene Name：ANO10 TMEM16K

Protein Name：Anoctamin-10 (Transmembrane protein 16K)

Human Gene Id：55129

Human Swiss Prot No：Q9NW15

Mouse Swiss Prot No：Q8BH79

Immunogen：Synthesized peptide derived from human protein . at AA range: 431-480

Specificity：ANO10 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：72kD

Background： The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],

Function：function:May act as a calcium-activated chloride channel.,sequence caution:Contaminating sequence.,similarity:Belongs to the anoctamin family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Expression：Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.