Target：PORIM

Gene Name：TMEM123 KCT3 PSEC0111 UNQ641/PRO1271

Protein Name：Porimin (Keratinocytes-associated transmembrane protein 3) (KCT-3) (Pro-oncosis receptor inducing membrane injury) (Transmembrane protein 123)

Human Gene Id：114908

Human Swiss Prot No：Q8N131

Mouse Swiss Prot No：Q91Z22

Rat Swiss Prot No：Q5HZB0

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PORIM Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：22kD

Background： This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008],

Function：function:Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.,similarity:Belongs to the CD164 family.,tissue specificity:Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.