Target：PON3

Gene Name：PON3

Protein Name：Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)

Human Gene Id：5446

Human Swiss Prot No：Q15166

Mouse Swiss Prot No：Q62087

Rat Swiss Prot No：Q68FP2

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PON3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：38kD

Background： This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008],

Function：catalytic activity:A phenyl acetate + H(2)O = a phenol + acetate.,catalytic activity:An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.,function:Has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.,PTM:Glycosylated.,PTM:The signal sequence is not cleaved.,similarity:Belongs to the paraoxonase family.,

Subcellular Location：Secreted, extracellular space .

Expression： Hepatoma,Liver,Plasma,