Target：POLR3C

Fields：RNA polymerase;Cytosolic DNA-sensing pathway

Gene Name：POLR3C

Protein Name：DNA-directed RNA polymerase III subunit RPC3

Human Gene Id：10623

Human Swiss Prot No：Q9BUI4

Mouse Swiss Prot No：Q9D483

Immunogen：The antiserum was produced against synthesized peptide derived from human RPC3. AA range:191-240

Specificity：POLR3C Polyclonal Antibody detects endogenous levels of POLR3C protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：POLR3C;DNA-directed RNA polymerase III subunit RPC3;RNA polymerase III subunit C3;DNA-directed RNA polymerase III subunit C;RNA polymerase III 62 kDa subunit;RPC62

Observed Band(KD)：60kD

Background：disease:Antibodies against POLR3C were found in the sera of patients with systemic sclerosis (SSc).,function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation.,similarity:Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.,subunit:Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4.,

Function：disease:Antibodies against POLR3C were found in the sera of patients with systemic sclerosis (SSc).,function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation.,similarity:Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.,subunit:Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a P

Subcellular Location：Nucleus .

Expression： Cervix carcinoma,Lung,Ovary,