Target：POLR1E

Fields：RNA polymerase

Gene Name：POLR1E

Protein Name：DNA-directed RNA polymerase I subunit RPA49

Human Gene Id：64425

Human Swiss Prot No：Q9GZS1

Mouse Swiss Prot No：Q8K202

Immunogen：Synthesized peptide derived from the Internal region of human POLR1E.

Specificity：POLR1E Polyclonal Antibody detects endogenous levels of POLR1E protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：POLR1E;PAF53;PRAF1;DNA-directed RNA polymerase I subunit RPA49;RNA polymerase I subunit A49;DNA-directed RNA polymerase I subunit E;RNA polymerase I-associated factor 1;RNA polymerase I-associated factor 53

Observed Band(KD)：49kD

Background：function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.,similarity:Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with PAF49/CD3EAP. Also binds UBTF/UBF.,

Function：function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.,similarity:Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with PAF49/CD3EAP. Also binds UBTF/UBF.,

Subcellular Location：Nucleus, nucleolus .

Expression： Cervix,Lung,Placenta,