Target：PMVK

Fields：Terpenoid backbone biosynthesis;Metabolic pathways;Peroxisome

Gene Name：PMVK PMKI

Protein Name：Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2)

Human Gene Id：10654

Human Swiss Prot No：Q15126

Mouse Swiss Prot No：Q9D1G2

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PMVK Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：21kD

Background： This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011],

Function：catalytic activity:ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.,induction:By sterol.,pathway:Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonic acid pathway; isopentenyl-PP from (R)-mevalonic acid: step 2/3.,subunit:Monomer.,tissue specificity:Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta, and lung.,

Subcellular Location：Cytoplasm, cytosol .

Expression：Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.