Target：ATP1AL1

Fields：Oxidative phosphorylation;Metabolic pathways

Gene Name：ATP12A

Protein Name：Potassium-transporting ATPase alpha chain 2

Human Gene Id：479

Human Swiss Prot No：P54707

Mouse Swiss Prot No：Q9Z1W8

Rat Swiss Prot No：P54708

Immunogen：Synthesized peptide derived from ATP1AL1 . at AA range: 380-460

Specificity：ATP1AL1 Polyclonal Antibody detects endogenous levels of ATP1AL1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ATP12A;ATP1AL1;Potassium-transporting ATPase alpha chain 2;Non-gastric H(+)/K(+) ATPase subunit alpha;Proton pump

Observed Band(KD)：115kD

Background： The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

Function：catalytic activity:ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).,function:Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subunit:Composed of two subunits: alpha (catalytic) and beta.,tissue specificity:Found in skin and kidney.,

Subcellular Location：Apical cell membrane ; Multi-pass membrane protein .

Expression：Expressed in airway epithelial cells (at protein level) (PubMed:29391451). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).