Target：Ephrin-A2

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;PI3K-Akt signaling pathway;Axon guidance;MicroRNAs in cancer

Gene Name：EFNA2

Protein Name：Ephrin-A2

Human Gene Id：1943

Human Swiss Prot No：O43921

Mouse Gene Id：13637

Mouse Swiss Prot No：P52801

Immunogen：The antiserum was produced against synthesized peptide derived from human EFNA2. AA range:1-50

Specificity：Ephrin-A2 Polyclonal Antibody detects endogenous levels of Ephrin-A2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EFNA2;EPLG6;LERK6;Ephrin-A2;EPH-related receptor tyrosine kinase ligand 6;LERK-6;HEK7 ligand;HEK7-L

Observed Band(KD)：24kD

Background： This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008],

Function：similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5.,

Subcellular Location：Cell membrane ; Lipid-anchor, GPI-anchor .

Expression： Brain,