Target：EphB3

Fields：Axon guidance

Gene Name：EPHB3 ETK2 HEK2 TYRO6

Protein Name：Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)

Human Gene Id：2049

Human Swiss Prot No：P54753

Mouse Gene Id：13845

Mouse Swiss Prot No：P54754

Immunogen：Synthetic peptide from human protein at AA range: 650-700

Specificity：The antibody detects endogenous EphB3

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Ephrin type-B receptor 3 (EC 2.7.10.1;EPH-like tyrosine kinase 2;EPH-like kinase 2;Embryonic kinase 2;EK2;hEK2;Tyrosine-protein kinase TYRO6)

Background： Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-B family. Binds to ephrin-B1 and -B2.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Ubiquitous.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Cell projection, dendrite .

Expression：Ubiquitous.