Target：EP3

Fields：Calcium signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;Regulation of lipolysis in adipocytes;Human cytomegalovirus infection;Pathways in cancer

Gene Name：PTGER3

Protein Name：Prostaglandin E2 receptor EP3 subtype

Human Gene Id：5733

Human Swiss Prot No：P43115

Mouse Swiss Prot No：P30557

Immunogen：The antiserum was produced against synthesized peptide derived from human PTGER3. AA range:16-65

Specificity：EP3 Polyclonal Antibody detects endogenous levels of EP3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PTGER3;Prostaglandin E2 receptor EP3 subtype;PGE receptor EP3 subtype;PGE2 receptor EP3 subtype;PGE2-R;Prostanoid EP3 receptor

Observed Band(KD)：43kD

Background： The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],

Function：alternative products:Additional isoforms seem to exist,function:Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.