Target：ATF-6β

Fields：cGMP-PKG signaling pathway;Protein processing in endoplasmic reticulum;PI3K-Akt signaling pathway;Longevity regulating pathway;Adrenergic signaling in cardiomyocytes;TNF signaling pathway;Dopaminergic synapse;Insulin secretion;Estrogen signaling pathway;Thyroid hormone synthesis;Aldosterone synthesis and secretion;Relaxin signaling pathway;Cortisol synthesis and secretion;Parathyroid hormone synthesis, secretion and action;Cushing syndrome;Growth hormone synthesis, secretion and action;Prion disease;Cocaine addiction;Amphetamine addiction;Alcoholism;Hepatitis B;Human cytomegalovirus infection;Human T-cell leukemia virus 1 infection;Viral carcinogenesis;Chemical carcinogenesis - receptor activation

Gene Name：ATF6B

Protein Name：Cyclic AMP-dependent transcription factor ATF-6 beta

Human Gene Id：1388

Human Swiss Prot No：Q99941

Mouse Swiss Prot No：O35451

Immunogen：The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450

Specificity：ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ATF6B;CREBL1;G13;Cyclic AMP-dependent transcription factor ATF-6 beta;cAMP-dependent transcription factor ATF-6 beta;Activating transcription factor 6 beta;ATF6-beta;Protein G13;cAMP response element-binding protein-related protein;

Observed Band(KD)：90kD

Background： The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

Function：domain:The basic domain functions as a nuclear localization signal.,domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,function:Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.,PTM:During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cy

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .

Expression：Ubiquitous.