Target：eIF4E3

Gene Name：EIF4E3

Protein Name：Eukaryotic translation initiation factor 4E type 3

Human Gene Id：317649

Human Swiss Prot No：Q8N5X7

Mouse Gene Id：66892

Mouse Swiss Prot No：Q9DBB5

Immunogen：The antiserum was produced against synthesized peptide derived from human EIF4E3. AA range:141-190

Specificity：eIF4E3 Polyclonal Antibody detects endogenous levels of eIF4E3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EIF4E3;Eukaryotic translation initiation factor 4E type 3;eIF-4E type 3;eIF-4E3;eIF4E type 3;eIF4E-3

Observed Band(KD)：24kD

Background： EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008],

Function：function:Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.,similarity:Belongs to the eukaryotic initiation factor 4E family.,subunit:eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.,

Subcellular Location：cytoplasm,cytosol,mRNA cap binding complex,

Expression： Brain,