Target：AR-α2A

Fields：cGMP-PKG signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：ADRA2A

Protein Name：Alpha-2A adrenergic receptor

Human Gene Id：150

Human Swiss Prot No：P08913

Mouse Swiss Prot No：Q01338

Immunogen：The antiserum was produced against synthesized peptide derived from human ADRA2A. AA range:281-330

Specificity：AR-α2A Polyclonal Antibody detects endogenous levels of AR-α2A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADRA2A;ADRA2R;ADRAR;Alpha-2A adrenergic receptor;Alpha-2 adrenergic receptor subtype C10;Alpha-2A adrenoreceptor;Alpha-2A adrenoceptor;Alpha-2AAR

Observed Band(KD)：50kD

Background： Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008],

Function：function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression： Epithelium,Platelet,PNS,Testis,