Target：Arylsulfatase G
Fields：Lysosome
Gene Name：ARSG
Protein Name：Arylsulfatase G
Human Gene Id：22901
Human Swiss Prot No：Q96EG1
Mouse Gene Id：74008
Mouse Swiss Prot No：Q3TYD4
Rat Gene Id：303631
Rat Swiss Prot No：Q32KJ9
Immunogen：The antiserum was produced against synthesized peptide derived from human ARSG. AA range:251-300
Specificity：Arylsulfatase G Polyclonal Antibody detects endogenous levels of Arylsulfatase G protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ARSG;KIAA1001;Arylsulfatase G;ASG
Observed Band(KD)：65kD
Background： The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012],
Function：cofactor:Binds 1 calcium ion per subunit.,PTM:N-glycosylated.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,tissue specificity:Widely expressed.,
Subcellular Location：Lysosome . The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. .
Expression：Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
