Target：ARP

Gene Name：MANF

Protein Name：Mesencephalic astrocyte-derived neurotrophic factor

Human Gene Id：7873

Human Swiss Prot No：P55145

Mouse Swiss Prot No：Q9CXI5

Rat Swiss Prot No：P0C5H9

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human MANF. AA range:11-60

Specificity：ARP Polyclonal Antibody detects endogenous levels of ARP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MANF;ARMET;ARP;Mesencephalic astrocyte-derived neurotrophic factor;Arginine-rich protein;Protein ARMET

Observed Band(KD)：20kD

Background： The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014],

Function：response to unfolded protein, response to organic substance, response to protein stimulus,

Subcellular Location：Secreted . Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057). .

Expression： Testis,