Target：ARHGEF10

Gene Name：ARHGEF10

Protein Name：Rho guanine nucleotide exchange factor 10

Human Gene Id：9639

Human Swiss Prot No：O15013

Mouse Swiss Prot No：Q8C033

Immunogen：The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388

Specificity：ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARHGEF10;KIAA0294;Rho guanine nucleotide exchange factor 10

Observed Band(KD)：152kD

Background： This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],

Function：disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain.,

Subcellular Location：centrosome,cytosol,

Expression： Amygdala,Brain,Duodenum,Prostate,Testis,Uterus,