Target：ARHGAP22

Gene Name：ARHGAP22

Protein Name：Rho GTPase-activating protein 22

Human Gene Id：58504

Human Swiss Prot No：Q7Z5H3

Mouse Swiss Prot No：Q8BL80

Immunogen：The antiserum was produced against synthesized peptide derived from human RHG22. AA range:565-614

Specificity：ARHGAP22 Polyclonal Antibody detects endogenous levels of ARHGAP22 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARHGAP22;RHOGAP2;Rho GTPase-activating protein 22;Rho-type GTPase-activating protein 22

Observed Band(KD)：77kD

Background： This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Function：function:Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Mainly cytoplasmic. Some fraction is nuclear.,subunit:Interacts with VEZF1.,

Subcellular Location：Cytoplasm . Nucleus . Mainly cytoplasmic. Some fraction is nuclear (By similarity). .

Expression： Brain,Erythroleukemia,Lung,