Target：AR α2B

Fields：cGMP-PKG signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：ADRA2B

Protein Name：Alpha-2B adrenergic receptor

Human Gene Id：151

Human Swiss Prot No：P18089

Mouse Swiss Prot No：P30545

Immunogen：The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2B. AA range:161-210

Specificity：AR α2B Polyclonal Antibody detects endogenous levels of AR α2B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADRA2B;ADRA2L1;ADRA2RL1;Alpha-2B adrenergic receptor;Alpha-2 adrenergic receptor subtype C2;Alpha-2B adrenoreceptor;Alpha-2B adrenoceptor;Alpha-2BAR

Molecular Weight(Da)：50kD

Background： This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014],

Function：function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.,polymorphism:A rare polymorphic framshift in position 451 produces a protein of 542 residues.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. .

Expression： Pooled,