Target：EDG-3

Fields：Sphingolipid signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：S1PR3

Protein Name：Sphingosine 1-phosphate receptor 3

Human Gene Id：1903

Human Swiss Prot No：Q99500

Mouse Gene Id：13610

Mouse Swiss Prot No：Q9Z0U9

Immunogen：The antiserum was produced against synthesized peptide derived from human EDG3. AA range:115-164

Specificity：EDG-3 Polyclonal Antibody detects endogenous levels of EDG-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：S1PR3;EDG3;Sphingosine 1-phosphate receptor 3;S1P receptor 3;S1P3;Endothelial differentiation G-protein coupled receptor 3;Sphingosine 1-phosphate receptor Edg-3;S1P receptor Edg-3

Observed Band(KD)：42kD

Background： This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008],

Function：function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.