Target：EF-Tu

Gene Name：TUFM

Protein Name：Elongation factor Tu mitochondrial

Human Gene Id：7284

Human Swiss Prot No：P49411

Mouse Gene Id：233870

Mouse Swiss Prot No：Q8BFR5

Rat Gene Id：293481

Rat Swiss Prot No：P85834

Immunogen：The antiserum was produced against synthesized peptide derived from human TUFM. AA range:301-350

Specificity：EF-Tu Polyclonal Antibody detects endogenous levels of EF-Tu protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TUFM;Elongation factor Tu; mitochondrial;EF-Tu;P43

Observed Band(KD)：50kD

Background： This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008],

Function：disease:Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4) [MIM:610678]. COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.,function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.,similarity:Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.,

Subcellular Location：Mitochondrion .

Expression： Brain,Cajal-Retzius cell,Heart,Kidney,Liver,Lung,Placenta,P