Target：EDN2

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Renin secretion

Gene Name：EDN2

Protein Name：Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2)

Human Gene Id：1907

Human Swiss Prot No：P20800

Mouse Swiss Prot No：P22389

Rat Swiss Prot No：P23943

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：EDN2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：19kD

Background： This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],

Function：function:Endothelins are endothelium-derived vasoconstrictor peptides.,similarity:Belongs to the endothelin/sarafotoxin family.,tissue specificity:Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.,

Subcellular Location：Secreted.

Expression：Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.